中国医学科学院血液病医院(血液学研究所)研究员,北京协和医学院(长准聘系列)助理教授,博士生导师,获国家级人才计划青年项目。实验室的研究兴趣为血液系统疾病的功能基因组和基因治疗,具体研究方向为1)新型基因编辑工具研发,2)CRISPR高通量功能筛选,3)遗传性疾病基因治疗。研究成果发表在Cell Stem Cell、Journal of Clinical Investigation和Nature Communications等期刊。
13.
Marsha M. Wheeler#, Adrienne M. Stilp#, Shuquan Rao#,
Bjarni V. Halldórsson, Doruk Beyter, Jia Wen, Anna V. Mikhaylova, Caitlin P.
McHugh, John Lane, Minzhi Jiang, et al. Whole genome sequencing
identifies common and rare structural variants contributing to hematologic
traits in the NHLBI TOPMed program. Nat Commun 2022.
12. Yao
Yao#, Jiaxuan Cao#, Wentian Wang, Boya Liu, Xiaolei Pei,
Lei Zhang, Shuquan Rao*. Highly efficient
one-step tagging of endogenous genes in primary cells using CRISPR-Cas
ribonucleoproteins. The CRISPR Journal 2022.
11. Yao
Yao#, Hongfei Song#, Fanshuang Zhang#, Jibin
Liu, Quansheng Feng, Shuquan Rao*, Cen Jiang*.
Genetic predisposition to blood cell indices in relation to severe COVID-19. J
Med Virol 2022 Aug 29.
10. Fuquan
Zhang#*, Shuquan Rao#, Hongbao Cao,
Xiangrong Zhang, Qiang Wang, Yong Xu, Jing Sun, Chun Wang, Jiu Chen, Xijia Xu,
et al. Genetic evidence suggests
posttraumatic stress disorder as a subtype of major depressive disorder. J
Clin Invest 2022, 132 (3):e145942.
9. Shuquan
Rao#, Ancha Baranova#, Hongbao Cao, Jiu Chen,
Xiangrong Zhang, Fuquan Zhang*. Genetic mechanisms of COVID-19 and its association with
smoking and alcohol consumption. Brief Bioinform 2021.
8. Shuquan
Rao#*, Yao Yao#, Daniel E. Bauer*. Editing
GWAS: experimental approaches to dissect and exploit disease-associated genetic
variation. Genome Med 2021, 13:41.
7. Shuquan
Rao#, Yao Yao#, Josias Soares de Brito#,
Qiuming Yao, Anne H Shen, Ruth E Watkinson, Alyssa L Kennedy, Steven Coyne,
Chunyan Ren, Jing Zeng, et al. ELANE neutropenia
pathogenicity dissected by human hematopoietic stem cell gene editing. Cell
Stem Cell 2021, 28:1-13. Featured article. See
commentary in New England Journal of Medicine by Prof. Julia
Skokowa and Cell Stem Cell by Prof. Marshall S. Horwitz.
6. Yao
Hu#, Adrienne M Stilp#, Caitlin P McHugh#, Shuquan
Rao#, Deepti Jain, Xiuwen Zheng, John Lane, Sébastian Méric
de Bellefon, Laura M Raffield, Ming-Huei Chen, et al. Whole-genome sequencing association analysis of
quantitative red blood cell phenotypes: The NHLBI TOPMed program. Am
J Hum Genet 2021.
5. Yao
Yao#, Fei Ye#, Kailong Li#, Peng Xu, Wenjie
Tan, Quansheng Feng, Shuquan Rao*. Genome
and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21. 31
locus associated with severe COVID-19. Signal
Transduct Target Ther 2021.
4. Yao
Yao, Jia Yang, Qian Qin, Chao Tang, Zhidan Li, Li Chen, Kailong Li, Chunyan
Ren, Lu Chen*, Shuquan Rao*. Functional
annotation of genetic associations by transcriptome-wide association analysis
provides insights into neutrophil development regulation. Commun
Biol 2020, 3(1): 790.
3. Sha
Liu#, Shuquan Rao#, Yong Xu#,
Jun Li#, Hailiang Huang, Xu Zhang, Hui Fu, Qiang Wang, Hongbao Cao,
Ancha Baranova, Chunhui Jin*, Fuquan Zhang*. Identifying common genome-wide risk genes for major psychiatric traits. Hum
Genet 2020, 139(2): 185-198.
2. Shuquan Rao#*, Na
Luo#, Jing Sui, Qi Xu, Fuquan
Zhang. Effect of the SIRT1 gene on regional cortical grey matter
density in the Han Chinese population. Br J Psychiatry 2018.
1. Yao
Yao#, Jia Yang#,
Yimin Xie, Hai Liao, Baoying Yang, Qi Xu, Shuquan Rao*. No Evidence for Widespread Positive Selection Signatures
in Common Risk Alleles Associated with Schizophrenia. Schizophr
Bull 2018.