我们主要从事骨髓造血衰竭症（BMF）的基础与临床研究，新药临床试验，新的诊断技术研究及新的治疗手段探索。过去20余年，我们于国内率先应用强化免疫抑制疗法及中西医结合疗法治疗重型再生障碍性贫血（SAA），其疗效居国际领先水平。于国际上首次前瞻性比较了四种免疫抑制疗法治疗SAA的疗效。独创CsA/LMS、雄激素联合中医治疗SAA，颠覆了AA环孢素治疗的传统模式。我们探索性研究了BMF的病理生理机制，对调节性T细胞在BMF病理机制中的作用和功能、T淋巴细胞异常及MDS相关基因与AA相关性等进行了系统深入研究。我们目前的研究是过去对BMF基础与临床研究的延伸。目前我们正在研究CD8+CD28-调节性T细胞在AA病理生理机制中的作用。

我们实验室欢迎有兴趣的学者加入到我们的队伍。

2000/09–2004/12 中国协和医科大学血液内科博士

1993/09–1996/08 中国协和医科大学血液内科硕士

1983/09–1989/08 同济医科大学临床医学

2008/10-至今    中国医学科学院血液病医院主任医师

2003/08-2008/09  中国医学科学院血液病医院副主任医师

2001/02-2003/08  AsahiKASEI Corporation博士后工作站访问学者

1997/02-2001/01  中国医学科学院血液病医院主治医师

1996/08-1997/01  中国医学科学院血液病医院住院医师

1989/08-1993/07  中国医学科学院血液病医院住院医师

(1). 增进造血干细胞体内迁移及造血重建能力的可行性移植策略研究，国家自然基金委面上项目，30571762，主持，2006/01-2008/12

(2). 骨髓造血衰竭症癌基因/抑癌基因突变研究，中央高校新兴与交叉科研团队项目，2012N05，主持，2012.12-2013.12

(3). miR-18a-5p介导的骨髓衰竭的病理生理机制，国家自然基金委面上项目,81470289，主持，2015/01-2018/12

(4). CD8+CD28-调节性T细胞诱导的再生障碍性贫血病愈机制研究， 国家自然基金委面上项目,81770119，主持，2018/01-2021/12

(1). Gao J, Li Y, Lu S, Wang M, Yang Z, Yan X, Zheng Y (Corresponding author). Enhanced in vivo motility of human umbilical cord blood hematopoietic stem/progenitor cells introduced via intra-bone marrow injection into xenotransplanted NOD/SCID mouse. Exp Hematol. 2009 Aug;37(8):990-997.

(2). Li Y, Li X, Ge M, Shi J, Qian L, Zheng Y (Corresponding author), Wang J. Long-term follow-up of clonal evolutions in 802 aplastic anemia patients: a single-center experience. Ann Hematol, 2011 May;90(5):529-537.

(3). Ge M, Zheng Y (Corresponding author), Li X, Shi J, Ge J, Li H, Feng S. The polymorphisms of T cell-specific TBX21 and STAT4 genes may contribute to the susceptibility of Chinese individuals to aplastic anemia. Hum Immunol. 2012 Jan;73(1):118-121.

(4). Meili Ge, Xingxin Li, Jun Shi, Yingqi Shao, Yizhou Zheng. Clinical features and prognostic factors of Asian patients with paroxysmal nocturnal hemoglobinuria: results from a single center in China. Ann Hematol, 2012 Jul;91(7):1121-1128.

(5). Shi J, Ge M, Lu S, Li X, Shao Y, Huang J, Huang Z, Zhang J, Nie N, Zheng Y. Intrinsic impairment of CD4+CD25+ regulatory T cells in acquired aplastic anemia. Blood. 2012 Aug 23;120(8):1624-1632.

(6). Ge M, Zheng Y(Corresponding author), Li X, Lu S, Li H, Chen F, Chen D, Shao Y, Shi J, Feng S. Differential expression profile of Th1/Th17/Th2-related chemokines and their receptors in patients with acquired bone marrow failure syndromes. Hum Immun; 2012, 74(2):176-80.

(7). Li X, Shi J, Ge M, Shao Y, Huang J, Huang Z, Zhang J, Nie N, Zheng Y. Outcomes of Optimized over Standard Protocol of Rabbit Antithymocyte Globulin for Severe Aplastic Anemia: A Single-Center Experience. PLoS One. 2013;8(3):e56648.

(8). Li X, Shao Y, Ge M, Shi J, Huang J, Huang Z, Zhang J, Nie N, Zheng Y. A promising immunosuppressive strategy of cyclosporine alternately combined with levamisole is highly effective for moderate aplastic anemia. Ann Hematol. 2013; 92(9):1239-47. doi: 10.1007/s00277-013-1764-7.

(9). Shao Y, Li X, Shi J, Ge M, Huang J, Huang Z, Zhang J, Nie N, Zheng Y. Cyclosporin combined with levamisole for refractory or relapsed severe aplastic anaemia. Br J Haematol. 2013;162(4):552-5.

(10). Wang M, Nie N, Feng S, Shi J, Ge M, Li X, Shao Y, Huang J, Zheng Y. The polymorphisms of human leukocyte antigen loci may contribute to the susceptibility and severity of severe aplastic anemia in Chinese patients. Hum Immunol. 2014 Jun 27.

(11). Wu Q, Zhang J, Shi J, Ge M, Li X, Shao Y, Yao J, Zheng Y. Increased Bone Marrow (BM) Plasma Level of Soluble CD30 and Correlations with BM Plasma Level of Interferon (IFN)-γ, CD4/CD8 T-Cell Ratio and Disease Severity in Aplastic Anemia. PLoS One. 2014 Nov 10;9(11):e110787.

(12). Ge M, Yu W, Shi J, Zhang J, Wang M, Feng S, Li X, Shao Y, Zheng Y. TRAF1/C5 rs10818488 polymorphism is not a genetic risk factor for acquired aplastic anemia in a Chinese population. Hum Immunol. Hum Immunol. 2015 Jan; 76(1):19-21.

(13). Huang J, Ge M, Lu S, Shi J, Li X, Zhang J, Wang M, Yu W, Shao Y, Huang Z, Zhang J, Nie N, Zheng Y. Mutations of ASXL1 and TET2 in aplastic anemia. Haematologica. 2015 May;100(5):e172-5.

(14). Zhang J, Wu Q, Shi J, Ge M, Li X, Shao Y, Yao J, Zheng Y. Involvement of interleukin-21 in the pathophysiology of aplastic anemia. Eur J Haematol. 2015 Jul;95(1):44-51.

(15). Ge M, Shi J, Li X, Shao Y, Huang J, Huang Z, Zhang J, Nie N, Zheng Y. Clinical features and survival of asian pediatric patients with paroxysmal nocturnal hemoglobinuria: results from a single center in china. Acta Haematol. 2015;134(1):1-6.

(16). Zhang J, Wu Q, Yao J, Nie N, Ge M, Shi J, Zheng Y. Basal level of Th17 immune response is not enhanced in aplastic amemia. Cytokine. 2015 Aug; 74(2):331-4.

(17). Li X, Shi J, Wang M, Nie N, Shao Y, Ge M, Huang J, Huang Z, Zhang J, Zheng Y. Cyclosporine Combined with Levamisole for Lower-Risk Myelodysplastic Syndromes. Acta Haematol. 2015 Apr 24;134(3):138-145.

(18). Wang M, Li X, Shi J, Shao Y, Ge M, Huang J, Huang Z, Zhang J, Nie N, Zheng Y. Outcome of a novel immunosuppressive strategy of cyclosporine, levamisole and danazol for severe aplastic anemia. Int J Hematol. 2015 Aug;102(2):149-56.

(19). Huang J, Ge M, Lu S, Shi J, Li X, Zhang J, Wang M, Yu W, Shao Y, Huang Z, Zhang J, Nie N, Zheng Y. ASXL1 single nucleotide polymorphisms rs62206933, rs117901891, and rs74638057 identify a subgroup of acquired aplastic anemia in Chinese Han patients. Int J Lab Hematol. 2015 Dec;37(6):e163-7.

(20). Yu W, Ge M, Lu S, Shi J, Li X, Zhang J, Wang M, Huang J, Shao Y, Huang Z, Zhang J, Nie N, Zheng Y. Anti-inflammatory effects of interleukin-35 in acquired aplastic anemia. Cytokine. 2015 Dec;76(2):409-416.

(21). Huang J, Ge M, Lu S, Shi J, Yu W, Li X, Wang M, Zhang J, Feng S, Dong S, Cheng X, Zheng Y. Impaired Autophagy in Adult Bone Marrow CD34+ Cells of Patients with Aplastic Anemia: Possible Pathogenic Significance. PLoS One. 2016 Mar 1;11(3):e0149586.

(22). Yu W, Ge M, Shi J, Li X, Zhang J, Wang M, Shao Y, Zheng Y. Role of vitamin D receptor gene polymorphisms in aplastic anemia: a case-control study from China. Int J Lab Hematol. 2016 Jun; 38(3):273-83.

(23). Li X, Feng Y, Wang H, Song M, Jin J, Cui Z, Zheng Y. Nutritional status survey of aplastic anemia patients - a single center experience in China. Appl Nurs Res. 2016 May; 30:142-7.

(24). Zhang J, Wu Q, Zheng Y. Persistent elevated bone marrow plasma levels of thrombopoietin in patients with aplastic anemia. Cytokine. 2016 Jun 3; 85:11-13.

(25). Yu W, Ge M, Lu S, Shi J, Feng S, Li X, Zhang J, Wang M, Huang J, Shao Y, Huang Z, Zhang J, Nie N, Zheng Y. Decreased expression of vitamin D receptor may contribute to the hyperimmune status of patients with acquired aplastic anemia. Eur J Haematol. 2016 May; 96(5):507-16.

(26). Li J, Ge M, Lu S, Shi J, Li X, Wang M, Huang J, Shao Y, Huang Z, Zhang J, Nie N, Zheng Y. Pro-inflammatory effects of the Th1 chemokine CXCL10 in acquired aplastic anaemia. Cytokine. 2017 Jun;94:45-51.

(27). You Y, Huo J, Lu S, Shao Y, Ge M, Shi J, Li X, Huang J, Huang Z, Zhang J, Wang M, Nie N, Zheng Y.The diverse expression of the WT1 gene in patients with acquired bone marrow failure syndromes. Leuk Lymphoma. 2018 Apr;59(4):950-957.

(28). Shao Y, Feng S, Huang J, Huo J, You Y, Zheng Y. A unique homozygous WRAP53 Arg298Trp mutation underlies dyskeratosis congenita in a Chinese Han family. BMC Med Genet. 2018 Mar 7; 19(1):40.

(29). You Y, Huo J, Lu S, Shao Y, Ge M, Shi J, Li X, Huang J, Huang Z, Zhang J, Wang M, Nie N, Zheng Y. The diverse expression of the WT1 gene in patients with acquired bone marrow failure syndromes. Leuk Lymphoma. 2018 Apr; 59(4):950-957.

(30). You Y, Huo J, Huang J, Wang M, Shao Y, Ge M, Li X, Huang Z, Zhang J, Nie N, Zheng Y. Contribution of autophagy-related gene 5 variants to acquired aplastic anemia in Han-Chinese population. J Cell Biochem. 2019 Feb 14.

(31). Ru YX, Dong SX, Zhao SX, Li Y, Liang HY, Zhang MMF, Zhu X, Zheng Y. One cell one niche: hematopoietic microenvironments constructed by bone marrow stromal cells with fibroblastic and histiocytic features. Ultrastruct Pathol. 2019 May 28:1-9.

(32). Huo J, Zhang L, Ren X, Li C, Li X, Dong P, Zheng X, Huang J, Shao Y, Ge M, Zhang J, Wang M, Nie N, Jin P, Zheng Y. Multifaceted characterization of the signatures and efficacy of mesenchymal stem/stromal cells in acquired aplastic anemia. Stem Cell Res Ther. 2020 Feb 13;11(1):59.

(33). Huo J, Li X, Shao Y, Ren X, Ge M, You Y, Huang J, Zhang J, Wang M, Nie N, Jin P, Zheng Y. Long-term follow-up of a novel immunosuppressive strategy of cyclosporine alternatively combined with levamisole for severe aplastic anemia. Ann Hematol. 2020 Aug; 99(8):1727-1734.

(34). Ren X, Li X, Huo J, You Y, Huang J, Shao Y, Ge M, Huang Z, Zhang J, Wang M, Jin P, Nie N, Zheng Y. Small PNH clones detected by fluorescent aerolysin predict a faster response to immunosuppressive therapy in patients with severe aplastic anaemia. Hematology. 2020 Dec; 25(1):348-355.